Year-end Sale % OFF 
Abstract
The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration.
Highlights
Cell communication and cell migration are key phenomena for development, tissue repair, and immune response; coordination of these responses are key for sustaining life [1–4]
We summarize the contribution of PANX channels during cell migration, emphasizing PANX1, that has been more widely studied
We have focused on immune cells as the integration of cell communication and cell migration is key for their function, despite mainly migrating as single cells
Summary
Cell communication and cell migration are key phenomena for development, tissue repair, and immune response; coordination of these responses are key for sustaining life [1–4]. A fine coordination of leukocyte communication is required for migration to clear an infection, or recruit other migrating cells towards an injury site. Immune cell migration follows the general rules of cell migration, and depends on. The study of immune cell migration is directly linked to development of new techniques to monitor the behavior of these cells in their native microenvironment [5, 12, 13], this is still very challenging. Motility has been studied in models with different levels of microenvironment complexity (i.e., 1D, 2D, and 3D), topographies (that do or do not impose cellular deformation), or that mimic their transmigration through tissue layers [6, 13, 14]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
