Abstract
Background: Borderline resectable pancreatic carcinoma (BRPC) as defined by NCCN guidelines, remains a challenging surgical problem, particularly in obtaining negative margins. In this study, surgical resection with irreversible electroporation for margin enhancement was evaluated to determine the long-term outcomes in BRPC. Methods: Patients with BRPC were included; those who underwent surgical resection with IRE (SIRE) were compared to those undergoing surgical resection alone (SR). The SR cohort was case-matched to demographic, operative, and oncologic parameters. Patients with concomitant vascular resection were excluded. Primary outcome measures included overall survival and disease recurrence. Results: Twenty patients were evaluated, ten in each group. Median overall survival was numerically higher in the SIRE group (13 months vs. 8 months, “p = 0.72”). At 2 years, SIRE patients had improved survival versus SR alone (70% vs. 20%, “p = 0.0145”). 1-year recurrence was numerically less in the SIRE group (20% vs. 30%, “p = 0.9770”). Conclusion: Surgical resection with IRE margin enhancement for BRPC may improve long term survival.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
