Abstract
Owing to the intrinsic ability of stem cells to target the tumor environment, stem cell membrane-functionalized nanocarriers can target and load active anticancer drugs. In this study, a strategy that focuses on stem cells that self target pancreatic cancer cells was deveolped. In particular, malignant deep tumors such as pancreatic cancer cells, one of the intractable tumors that currently have no successful clinical strategy, are available for targeting and destruction. By gaining the targeting ability of stem cells against pancreatic tumor cells, stem cell membranes can encapsulate nano polylactide-co-glycolide (PLGA) loaded with doxorubicin to target and reduce deep pancreatic tumor tissues. Considering the lack of known target proteins on pancreatic tumor cells, the suggested platform technology could be utilized for targeting any malignant tumors in which surface target receptors are unavailable. This article is protected by copyright. All rights reserved.
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