Abstract
Pancreatic reg proteins are exocrine proteins which are mitogenic to pancreatic ductal and ∃-cells (1,2). Using multiple alignment sequence comparison of the reg proteins with known mitogenic activity, we identified an amino acid sequence (RegP) highly conserved between rat, mouse and human reg’s (3), and postulated that it is the bioactive fragment. This sequence contained an ‘WIGL’ amino acid motif, considered important in calcium-dependant lectins. We also postulated that the action of reg would be through activation of mitogen-activated protein kinases (MAPK).
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