Abstract
A 66-year-old woman, who had undergone left nephrectomy for a primary renal cell carcinoma 17 years before, was found to have each tumor in the pancreatic body and tail, respectively. Distal pancreatectomy was performed. Histologically both tumors were found clear cell-type carcinoma, which closely resembled the renal cell carcinoma resected 17 years before in the morphological features. Renal cell carcinoma most commonly metastasizes to the lung, followed by liver, bone marrow, and adrenal gland in this order. The pancreas is an uncommon site of metastasis, and the frequency is reportedly about 2%. Moreover, resection of the metastatic lesion in the pancreas is hardly performed, and only 17 operated cases could be seen in the literature. Fourteen out of the 17 cases of which morphological features were clarified had also clear cell-type carcinoma. This case is interesting in another aspect that it had two metastatic lesions. In this case a pancreatic endocrinoma was suspected preoperatively, but no endocrinologic abnormal findings were revealed. A possibility of functioning tumor was denied, however, we had difficulties in differentiation between metastatic tumors and non-functioning tumors.
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