Abstract
Serum antitrypsin (SAT) and serum antichymotrypsin (SACHT) activities were determined by simple colorimetric procedures in sera of 80 control individuals, 27 pregnant women, and 136 patients who had acute or relapsing pancreatitis, acute or chronic cholecystitis and cholelithiasis, hepatitis or cirrhosis with liver cell necrosis, active duodenal ulcer, chronic obstructive pulmonary disease with superimposed infection, carcinoma of the breast, and various types of metastatic carcinomas. Compared with the controls, all groups had significant elevations of both SAT and SACHT activities except patients with primary and localized carcinoma of the breast, who had no significant change in SAT or SACHT activity, whereas patients with hepatitis or cirrhosis appeared to have increased SACHT activity. When results in patients with acute or relapsing pancreatitis were compared with those in patients with other disorders which resemble pancreatitis clinically, the SAT determination appeared useful in differentiating pancreatitis from hepatitis and cirrhosis, and the SACHT determination was useful in ruling out active duodenal ulcer.
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