Abstract
Pure natural porcine secretin infused at a constant rate intravenously in successively increasing doses produced a pancreatic dose-response curve for rate of flow and rate of bicarbonate output almost identical with that obtained by rapidly injected intravenous doses in 6 healthy subjects. The mean maximal bicarbonate output was achieved at the dose of 0.9 U of secretin per kg either as a rapid intravenous injection or by constant infusion during 1 hr further. Increment in dose increased the pancreatic response insignificantly. It is suggested that a stepwise increase in the dose of intravenously infused secretin is an effective and convenient procedure to obtain the entire pancreatic dose-response curve to secretin in a 1- to 3-day examination in man.
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