Abstract
Abstract Objective Pediatric pancreatic cystic lesions (PPCL) are uncommon and differ from adult pancreatic cystic lesions. Literature is limited on the etiologies, evaluation, and management of PPCL. A multidisciplinary working group formed to provide a comprehensive description of PPCL and recommend best available evidence-based evaluation and management. Methods The PPCL working group performed a scoping review by two methods: 1) a targeted literature review to describe PPCL, and 2) a systematic literature review for management recommendations for PPCL. The systematic review was completed using a two-stage sifting approach: title and abstract screening followed by a full text review. Results 131 studies were included in the systematic review and an additional 20 were included in the targeted search to complete a comprehensive list of PPCL. 5 neoplastic PPCL and 10 non-neoplastic PPCL were identified, and prevalence of different cystic lesions differs widely in adults and children. Recommendations on evaluation and management of PPCL are presented based on best available evidence. Conclusions We present a comprehensive review and evidence-based management recommendations with management algorithms for pediatric pancreatic cystic lesions. Given the rarity of many of these entities, this review also highlights many aspects of PPCL which are not adequately described in the current literature.
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