Pancreatic cancer with diabetes: the RegIV protein expression and its clinical value

Abstract

Objective To evaluate the RegⅣ protein expression profile in pancreatic cancer with or without diabetes,and to define the contribution of Reg Ⅳ in pancreatic cancer development.Methods The expressions of RegⅣ protein with or without type 2 diabetes in human pancreatic cancer tissue was detected by immunohistochemistry,in order to analyze its relationship with pancreatic cancer progression.Results The positive expression rate of RegⅣ in 60 patients with pancreatic cancer was 71.7 ％00 (43/60).The positive expression rate of pancreatic cancer tissue was significantly higher than normal pancreatic tissue (30.0％,x2 =10.97,P＜0.05).The prevalence of RegⅣ proteinpositive pancreatic cancer 87.8％ (43/49) was significantly higher than the negative pancreatic cancer54.8％ (17/31) (OR=5.90,95％ CI 1.90-17.89).Analysis using the Spearman correlation,overexpression of RegⅣ protein in pancreatic cancer resulted in accelerated diabetes (rs =0.331,P＜0.05).Overexpression of RegⅣ protein in pancreatic cancer and with diabetes were significantly correlated with TNM stage,tumor size,lymph node metastasis and degree of differentiation on histology,but not with age and gender.Conclusions RegⅣ protein overexpresses in pancreatic cancer patients with diabetes and plays an important role in the development of pancreatic cancer.It may be used as a predictor for patients with diabetes and pancreatic cancer. Key words: Pancreatic neoplasms; Diabetes mellitus,type 2; Immunohistochemistry