Pancreatic cancer associated micro-RNA

Abstract

Pancreatic cancer, known as the king of cancer, is a common malignant tumor of digestive tract, with a high degree of malignancy, difficult diagnosis and treatment, and a 5-year survival rate1%, is one of the malignancies with the worst prognosis. Therefore, there is an urgent need for better methods to improve the diagnostic accuracy and better prognosis of pancreatic cancer. Targeted therapy and accurate monitoring of prognosis is one of the key topics of research. Since 2004, when the relationship between micro-RNA and cancer was first revealed, there has been a great deal of interest in the research of micro-RNA. Related categories have been identified as being associated with other cancers, such as lung cancer, and drugs that use micro-RNA to treat cancer have emerged, but only during clinical trials. In this review, we will discuss the relationship between micro-RNA and pancreatic cancer and specifically elaborate microRNA-125a-5p、microRNA-125b、 microRNa-423-3p、microRNa-let-7a. At the same time, we summarize the difficulties in using microRNA for targeted therapy and the current clinical situation.