Abstract
Circulatory impairment is known to be an important factor in the deterioration of acute pancreatitis. We reported a canine model of chronic ischemic pancreatitis and the first successful model resembling human chronic alcoholic pancreatitis. Using this model, we investigated the significance of pancreatic tissue blood flow. There was pancreatic tissue ischemia in a model of chronic alcoholic pancreatitis. We conclude that pancreatic tissue ischemia is an etiological factor involved in chronic pancreatitis, and that ischemia acts as an aggravating factor of chronic alcoholic pancreatitis.
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