Abstract
The present study was designed to examine the effect of hypophysectomy upon gastric and pancreatic D cell function by determining the concentration of somatostatin-like immunoreactivity (SLI) in the venous effluents of the pancreas and stomach in response to an intragastric liver meal and acid load. In five sham-hypophysectomized (sham-hypox) control dogs, mean inferior vena cava SLI levels increased by 100 pg/ml above baseline in response to the liver meal and rose by an additional 450 pg/ml after the intragastric acid load. In the four hypophysectomized (hypox) dogs, mean inferior vena cava SLI levels did not differ significantly from the controls either before or after the liver meal, but decreased below baseline levels in response to the acid load, differing significantly from the values of the sham-hypox dogs. Pancreatic vein SLI levels of the sham-hypox dogs rose significantly by 600 pg/ml in response to the protein meal and increased further by 1000 pg/ml after the acid load. In the hypox group, pa...
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