Abstract
BackgroundPancreatic acinar cell carcinoma (ACC) is a rare tumor that constitutes 1% of all pancreatic neoplasms. Pancreatic ACC has unique characteristics in terms of biological behavior, imaging and prognosis.Case presentationThe present study reported two cases of pancreatic ACC confirmed by postoperative pathology and both cases exhibited several different imaging features and laboratory test results. Both cases had approximately 4 cm mass located in uncinate process of pancreas. Dilated intra- and extra-hepatic bile ducts was observed in one case, along with calcification. Heterogeneous enhancement of the tumor was exhibited in both patients with different intensities. Obstructive jaundice, elevated α-fetoprotein and CA 19–9 was found in one case, while the other case had normal liver function and tumor markers.ConclusionsIt was difficult to accurately diagnose pancreatic ACC before the operation despite its unique characteristics. Radical resection was the best treatment modality for resectable pancreatic ACC.
Highlights
Pancreatic acinar cell carcinoma (ACC) is a rare tumor that constitutes 1% of all pancreatic neoplasms
Accounting for only 1% of all pancreatic tumors, pancreatic acinar cell carcinoma (ACC), which originates from acinar elements of the exocrine pancreas, is a rare neoplasm [1, 2]
Suspected diagnosis of pancreatic ACC in patients who are fit for operation mainly relies on imaging examinations including enhanced computed tomography (CT) or magnetic resonance imaging (MRI), and confirmed diagnosis depends on postoperative pathology
Summary
Accounting for only 1% of all pancreatic tumors, pancreatic acinar cell carcinoma (ACC), which originates from acinar elements of the exocrine pancreas, is a rare neoplasm [1, 2]. Further examinations including enhanced abdominal and pelvic CT scans, chest X-ray, abdominal ultrasound, tumor markers, liver and renal function and coagulation function were performed. 281.2 μmol/L (normal: 5.0–21.0 μmol/L); direct bilirubin (DBIL), 212.6 μmol/L (normal: 0–6.8 μmol/L) Based on these results, an incorrect diagnosis of pancreatic neuroendocrine neoplasm was suspected before the operation and pancreaticoduodenectomy was performed on this patient. Case two A 79-year-old male patient, without any clinical symptoms, was found to have a pancreatic mass by ultrasound during routine physical examination. After he was admitted to our center, we performed further examinations including enhanced abdominal and pelvic CT scans, chest X-ray, tumor markers, liver and renal function, coagulation function, etc.
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