Abstract
The clinical and EEG features of Panayiotopoulos syndrome (PS) are reviewed and the pathophysiology discussed in a report from Guy's, St Thomas and Evelina Hospital for Children, London, UK.
Highlights
The clinical and EEG features of Panayiotopoulos syndrome (PS) are reviewed and the pathophysiology discussed in a report from Guy's, St Thomas" and Evelina Hospital for Children, London, UK
An attempt to explain the pathophysiology of PS distinguishes between idiopathic autonomic and symptomatic focal seizures with AS/S
PS is characterized by prolonged seizures with prominent autonomic features and multifocal EEG spikes occurring in developmentally normal children
Summary
The clinical and EEG features of Panayiotopoulos syndrome (PS) are reviewed and the pathophysiology discussed in a report from Guy's, St Thomas" and Evelina Hospital for Children, London, UK. Autonomic seizures are the clinical hallmark of PS. Other autonomic symptoms and signs (AS/S) include mydriasis, cardiorespiratory, gastrointestinal and thermoregulatory alterations, incontinence, coughing, and hypersalivation. Seizures may be purely autonomic or combined with other ictal features. About 10% patients have exclusively nonautonomic seizures.
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