Abstract
A pair of novel tetrahydrobenzofuran-2,5-dione derivatives with a unique C18 carbon skeleton, panamonon A (1) and B (2), was isolated from the leaves and twigs of Litsea panamonja (Nees) Hook. f. These new compounds contain an unprecedented C18 carbon skeleton consisting of a characteristic tetrahydrobenzofuran-2,5(3H,6H)-dione core with a biosynthetically extended geranyl side chain, designated as “panamonane”. Their structures were elucidated by comprehensive spectroscopic analyses. A plausible biosynthetic pathway for 1 and 2 is discussed. The isolates were evaluated for cytotoxic activities against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
