Abstract
Background: Hepatocellular carcinoma (HCC) is the leading cause of liver cancer and survival remains low due to poor treatment response. Surgery is the current first-line therapy for eligible candidates; however, patients relapse despite curative resection or require systemic treatment for advanced disease. Immune checkpoint inhibition (ICI) therapy has recently shown promise in the treatment of cancers, including HCC; yet, we do not know which patients may benefit. Additionally, the effect of viral infection on host long-term health and how the immune footprint left by viruses may impact immunotherapy response have not been explored. We hypothesized that viral infection alters host immunity in subtle ways, leaving a persistent footprint on the immune system, which may contribute to patient response to ICI.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.