Pan-carcinogenic analysis of Annexin A1 gene in human tumors: A bioinformatics study

Abstract

Background: Annexin A1 (ANXA1) and cancer appear to be related, based on emerging cell-based or animal research, but pan-cancer analysis is lacking. Objective: By using bioinformatics, we will examine the expression characteristics of the ANXA1 gene in pan-cancers. Methods: In collaboration with TCGA and GEO database, ANXA1 gene was analyzed pan-cancer, and through gene expression analysis, survival analysis, gene variation, immune infiltration, and enrichment analysis, ANXA1 played a role in the pathogenesis of different tumors. Results: A significant correlation has been found between ANXA1 expression and prognosis in some patients with tumors. The expression level of ANXA1 was correlated with the pathological stage of head and neck squamous cell carcinoma (HNSC) and thyroid carcinoma (THCA). The survival rates are related to the expression level of ANXA1 in different tumors. There is a strong correlation between the expression of ANXA1 and immune cell infiltration in some tumors and patients with sarcoma (SARC) and uterine corpus endometrial carcinoma (UCEC) have a higher mutation and amplification rate for the ANXA1 gene. ANXA1 may participate in the occurrence and development of tumor through "proteoglycans in cancer" signal pathways. Conclusion: The ANXA1 gene is involved in the pathogenesis of multiple kinds of tumors, and the study of its pathogenic mechanism may be an effective approach to treating tumors.