Abstract
Pan-Cancer Analysis of m5C Regulator Genes Reveals Consistent Epigenetic Landscape Changes in Multiple Cancers
Highlights
Cancers have become the second life-threatening malignancies, which contribute to almost 18.1 million people occurred, and 9.6 million death globally in 2018.[1]
Based on The Cancer Genome Atlas (TCGA) database, we uncovered that mutations and copy number variations (CNVs) of m5C regulatory genes were significantly correlated across 33 cancer types
M5C modification distributes in different types of RNAs and DNAs.[16,17,18] m5C modifications can even modify the destiny of cancer cells.[19] m5C regulators contain writers, erasers, and readers, which function as common epigenetic modification and contribute to pre-mRNA splicing, gene expression, gene silencing, nuclear export, genomic maintenance, and translation initiation modifications.[20,21] m5C could be used as a biomarker for disease progression, including various types of cancers.[22] m5C maintains open and closed chromatin states to control gene expression, genome editing, organismal development, and cellular differentiation.[18]
Summary
Based on The Cancer Genome Atlas (TCGA) database, we uncovered that mutations and copy number variations (CNVs) of m5C regulatory genes were significantly correlated across 33 cancer types. We assessed the correlation between the expression of individual m5C regulators and the activity of related hallmark pathways of cancers. After validating m5C regulators' expression based on their contributions to cancer development and progression, we observed their up-regulation within tumor-specific processes
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