Abstract
Pasteurella multocida can infect a wide range of host, including humans and animals of economic importance. Genomics studies on the pathogen have produced a large amount of omics data, which are deposited in GenBank but lacks a dedicated and comprehensive resource for further analysis and integration so that need to be brought together centrally in a coherent and systematic manner. Here we have collected the genomic data for 176 P. multocida strains that are categorized into 11 host groups and 9 serotype groups, and developed the open-access P. multocida Database (PamulDB) to make this resource readily available. The PamulDB implements and integrates Chado for genome data management, Drupal for web content management, and bioinformatics tools like NCBI BLAST, HMMER, PSORTb and OrthoMCL for data analysis. All the P. multocida genomes have been further annotated for search and analysis of homologous sequence, phylogeny, gene ontology, transposon, protein subcellular localization and secreted protein. Transcriptomic data of P. multocida are also selectively adopted for gene expression analysis. The PamulDB has been developing and improving to better aid researchers with identifying and classifying of pathogens, dissecting mechanisms of the pathogen infection and host response.
Highlights
Pasteurella multocida are a group of gram-negative coccobacillus-shaped organisms that are well known for causing diseases in a wide range of birds and mammals, including humans and economically important animal species [1]
The first complete genome sequence of P. multocida was sequenced from strain Pm70, which was isolated from avian host [6]
P. multocida strains are categorized by serotype and host so that can be quickly accessed from the front page (Figure 1A) and analysis tools that require strain selection
Summary
Pasteurella multocida are a group of gram-negative coccobacillus-shaped organisms that are well known for causing diseases in a wide range of birds and mammals, including humans and economically important animal species [1]. Infections by P. multocida can cause serious diseases, such as fowl cholera, swine atrophic rhinitis, bovine haemorrhagic septicaemia and lower respiratory tract infections (pneumonia and pleuritis), rabbit snuffles, human wound abscesses and meningitis following cat- or dog-inflicted injuries [2]. The first complete genome sequence of P. multocida was sequenced from strain Pm70, which was isolated from avian host [6]. 176 P. multocida genomes have been released in GenBank (https://www.ncbi.nlm.nih.gov/ genome/genomes/912), including 57 complete assemblies. The genomes have been used to identify important similarities and variations between strains, as well as phylogenetic relationships [2]. Genomic data provide important references for further studies on mechanisms of pathogenesis, host specificity and virulence [7,8,9]
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