Palpating particles using the acoustic radiation force: A new approach to magnetic particle imaging

Abstract

Magnetic particle imaging (MPI) is a tracer-based imaging technique that does not require radiation or a cyclotron. However, it does require bulky MRI-like hardware and does not produce a background tissue image. We propose a new approach to MPI that uses the acoustic radiation force to dynamically move iron nanoparticles through a magnetic field gradient, thereby changing their magnetic moment and producing a detectable signal in a receiver coil. An image could be formed by electronically steering the ultrasound focus to push particles at different spatial locations, like an ultrasonic palpation. This would enable a device that attaches to an ultrasound imaging transducer for simultaneous MPI and inherently registered ultrasound imaging. To test the feasibility of the technique, a cylindrical agar and graphite phantom was placed between a Maxwell coil pair which generated a linear field gradient across it, and particle signals were detected using a receiver solenoid. 2-ms ultrasound pulses were applied using a 6 MHz transducer to generate displacements along the magnetic field gradient. Signal measurements confirmed a lack of signal when iron nanoparticles were absent from the phantom, but the signal was detected when particles were present, with amplitudes that linearly increased with the gradient coil current.