Abstract
Palmoplantar pustulosis is a difficult-to-treat, immune-mediated skin disease that presents as sterile pustules on the palms and soles. While thought to be related to psoriasis vulgaris, precise biologics that target the same cytokines as psoriasis vulgaris have led to inadequate and difficult treatment. Topical corticosteroids have a broader anti-inflammatory profile compared with biologics but are limited by adverse events making chronic treatment unsuitable. We report the case of an 82-year-old patient who was successfully treated with topical roflumilast 0.3% once daily for the treatment of palmoplantar pustulosis that was refractory to topical corticosteroid use.
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