Abstract
We studied the effect of intraperitoneal and intratesticular administration of NKDTKIAKKNle-A(562-572) peptide and its palmotoylated analog NKDTKIAKK-Nle-A(562-572)-K(Palm)A to male rats on adenylate cyclase activity in the testicular membranes in vitro and on plasma testosterone levels. Peptide NKDTKIAKK-Nle-A(562-572)-K(Palm)A stimulated basal adenylate cyclase activity and reduced activity of the enzyme in testicular membranes stimulated by chorionic gonadotropin. After intratesticular administration in a dose of 200 μg/kg, it significantly increased testosterone so that 1, 3 and 5 h after administration its level was increased by 74, 44 and 35%, respectively. Administered intraperitoneally in a lower dose (50 μg/kg), the peptide had little effect on testosterone level. Unmodified peptide was inactive.
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