Abstract
ABSTRACTPropantheline bromide, an anticholinergic blocking agent, was found to nullify all sizable changes in skin resistance. Betazole hydrochloride, a histamine isomer causing flushing of the skin, had no detectable effect on changes in skin resistance. Betazole hydrochloride did decrease the level of skin resistance, and it is possible that increased vasodilatation “pumps” more conductive (saline‐like) substances into the skin. These results suggest that relatively rapid changes in skin resistance depend more upon sweat‐gland activity than upon changes in the fluid content of the skin, without denying the importance of the latter. It may be that the level of skin resistance at any one time depends upon a combination of sweat‐gland and vasomotor activities. Hence, as basal levels of skin resistance decrease, the relative magnitude of changes in skin resistance to stimuli also decreases (law of initial values).
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