Abstract

We have investigated the antibacterial activity of some new steroidal thiosemicarbazones and their Pd(II) metal complexes were prepared by the reaction of the thiosemicarbazones with [Pd(DMSO)2Cl2]. The steroidal thiosemicarbazones were prepared by the reaction of thiosemicarbazides with a steroidal ketone. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, FAB mass spectroscopic methods, elemental analyses and TGA analysis. The antibacterial activity of these compounds were tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The results showed that steroidal complexes are better inhibitors of both types of the bacteria (Gram-positive and Gram-negative) as compared to steroidal thiosemicarbazones. Compound Ia displays remarkable antibacterial activity as compared to amoxicillin.

Highlights

  • The chemistry of coordination metal complexes of thiosemicarbazone ligands have been receiving considerable attention primarily because of their bioinorganic relevance [1,2]

  • We report synthesis, characterization and antibacterial activity of Pd (II) complexes of steroidal thiosemicarbazones (STSC) against two Gram-positive and Gram-negative bacteria

  • The total % weight loss of the complexes corresponds to the loss of respective ligands after considering the transfer of one sulfur atom to the metal ion and the residues correspond to the palladium sulfide

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Summary

Introduction

The chemistry of coordination metal complexes of thiosemicarbazone ligands have been receiving considerable attention primarily because of their bioinorganic relevance [1,2]. There have been attempts [3] to determine structural correlations between metal ion complexes of thiosemicarbazones. The pharmacological action of the thiosemicarbazons is enhanced due to the presence of coordination metal ions [4,5]. N-substituted thiosemicarbazones showed a diversity of molecular geometries of the compounds, depending on the ligand, the salt used in synthesis and the method of compound synthesis. Substitution on the terminal N position can affect the coordination and biological properties. We report synthesis, characterization and antibacterial activity of Pd (II) complexes of steroidal thiosemicarbazones (STSC) against two Gram-positive and Gram-negative bacteria

Results and Discussion
IR spectral studies
NMR spectral analysis
Thermogravimetric analysis
FAB mass analysis
In-vitro anti-bacterial activity
General
Synthesis of thiosemicarbazones: A general method
Organism culture and in vitro screening
Conclusions

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