Abstract
The aminomethyl cyclopalladated complex is identified as a key intermediate for promoting the C–N bond activation of tertiary amines via reductive elimination and oxidative addition sequence. This strategy has enabled a palladium-catalyzed ring-closing reaction of enynols with aminals via methylene transfer and C–N bond activation, which provides rapid access to densely functionalized O-heterocycle containing allenic amines. The dual roles of the cyclopalladated complex, first as an aminomethylene-carrying reagent and then as a catalyst for C–N bond activation, have enabled a rare cascade redox-neutral methylene transfer and cyclization process that can simultaneously construct O-heterocycle framework and allenic amine functionality.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
