Abstract
A palladium catalyzed regioselective reaction of propargylic carbonate with thiophenols and benzene selenol is described. Atom-economic addition of thiols to propargylic carbonates provides an excellent opportunity for effective processes. The reaction proceeds via hydrothiolation to produce mono(arylthiol) alkenes and hydrothiolation followed by Tsuji-Trost type substitution to form bis(arylthiol) alkenes through single and double sequential attack by soft thio nucleophiles by control of the equivalence of thiophenols. This coupling reaction with good tolerance towards functional groups in both propargylic carbonates and thiols furnished a variety of highly functionalized alkenylation products in moderate to excellent yields via the formation of new C-S and C-Se bonds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
