Abstract
A practical, versatile, and efficient method for the palladium‐catalyzed direct cyanation of readily available acetanilides with K4[Fe(CN)6] as a safe cyanating agent through C–H bond activation with excellent C2 regioselectivity was developed. This finding represents a new strategy for the synthesis of N‐(2‐cyanoaryl)acetamides, which are important structural motifs in natural products and pharmaceuticals.
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