Abstract
A palladium-catalyzed oxidative cross-coupling reaction of conjugated enynones with organoboronic acids is developed. This reaction provides an efficient methodology for the synthesis of functionalized furan derivatives, including 2-alkenylfurans and furan-substituted 1,3-dienes. Palladium-carbene migratory insertion is proposed as the key step in these transformations. Notably, the β-hydride elimination process occurs in a stereoselective manner, resulting in the formation of double bonds with high (E)-selectivity.
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