Palladium-catalyzed oxidation of cyclohexanones to conjugated enones using molecular oxygen

Abstract

Oxidation of cyclohexanones into conjugated enones with molecular oxygen as oxidant was achieved by palladium catalysts. A catalyst system consists of 1 mol % Pd(OCOCF 3) 2 and 5,5′-dimethyl-2,2′-bipyridine accomplished maximum 84% yield for the oxidation of cyclohexanone and 51–78% yields for 4-substituted-cyclohexanones.