Abstract
AbstractWe report the extension and optimization of the [Pd(cinnamyl)Cl]2/DalPhos catalyst system, previously found effective for the mono‐α‐arylation of acetone, to the mono‐α‐arylation of a variety of carbonyl‐containing compounds with aryl halides and heteroaryl halides. Aryl methyl ketones, heteroaryl methyl ketones, propiophenones, malonates, and methoxyacetone can be α‐arylated under relatively mild conditions and in good yields. We also report the limitations of the ligand/catalyst system towards other classes of carbonyl‐containing compounds.
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