Palladium-catalyzed highly regio- and stereoselective carbon–carbon bond formation reaction of γ-substituted vinylaziridines with a silylated masked acyl cyanide reagent

Abstract

Highly regio- and stereoselective carbon–carbon bond formation reaction of vinylaziridines using a masked acyl cyanide reagent possessing a tert-butyldimethylsilyl group occurred in the presence of a catalytic amount of palladium complex in excellent yield. It is considered that these excellent selectivities are the result of three simultaneous conditions, strained leaving group, small nucleophile, and ligand with small cone-angle.