Abstract
Reaction of Na2[PdCl4] with two equivalents of amino- or acetylamino-pyridines (LH) affords trans-[PdCl2-(LH)2] {LH = 2-amino-3-methylpyridine (2-ampyH), 3-aminopyridine (3-apyH), 2-acetylamino-3-methylpyridine (2-acmpyH), 3-acetylamino-pyridine (3-acpyH)}. An X-ray crystal structure of trans-[PdCl2(2-ampyH)2] shows that the 2-ampy-H ligands are coordinated in a monodentate fashion via the nitrogen atoms of the pyridine rings. Treatment of trans-[PdCl2(2-acmpyH)2] with NEt3 affords the cyclometalated complex, trans-[Pd(κ2-2-acmpy)2], the X-ray structure of which shows that the 2-acmpy ligand is coordinated to palladium in a bidentate fashion via the nitrogen atom of the pyridine ring and oxygen. Reaction of trans-[PdCl2(LH)2] with two equivalents of sodium saccharinate affords the bis(saccharinate) complexes, trans-[Pd(sac)2(LH)2], in which the saccharinate anions are coordinated via the amide nitrogen atom.
Highlights
An X-ray crystal structure of trans-[PdCl2(2-ampyH)2] shows that the 2-ampy-H ligands are coordinated in a monodentate fashion via the nitrogen atoms of the pyridine rings
Treatment of trans[PdCl2(2-acmpyH)2] with NEt3 affords the cyclometalated complex, trans-[Pd(j2-2-acmpy)2], the X-ray structure of which shows that the 2-acmpy ligand is coordinated to palladium in a bidentate fashion via the nitrogen atom of the pyridine ring and oxygen
There is continued interest in the chemistry of saccharinate complexes as co-ligands in biological studies [1, 2], and a number of reports have recently appeared on the synthesis of platinum and palladium saccharinate complexes [3,4,5,6,7,8,9,10,11]
Summary
There is continued interest in the chemistry of saccharinate (sac) complexes as co-ligands in biological studies [1, 2], and a number of reports have recently appeared on the synthesis of platinum and palladium saccharinate complexes [3,4,5,6,7,8,9,10,11]. While saccharinate can bind to metal centres in a variety of different ways [1, 2] at the relatively soft Pd(II) and Pt(II) centres, it is always N-bound (Fig. 1). Continuing our recent studies in this area [12,13,14], we provide details of the synthesis of four new palladium saccharinate complexes, trans[Pd(sac)2(LH)2], derived from commercially available or readily prepared amino- or acetylamino-pyridines.
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