Palladium(II)‐Catalyzed Direct Arylations of Quinoxalin‐2(1H)‐ones with Arylsulfonyl Chlorides

Abstract

AbstractA palladium‐catalyzed desulfitative coupling of quinoxalin‐2(1H)‐ones with arylsulfonyl chlorides is described. C3‐Arylquinoxalin‐2(1H)‐ones are readily accessible by reacting various arylsulfonyl chloride derivatives with quinoxalin‐2(1H)‐ones. The arylsulfonyl chloride undergoes palladium‐catalyzed C−S and S−Cl bond cleavage, which leads to direct desulfitative cross‐coupling with the quinoxalin‐2(H)‐one. Chloro‐ and fluoro‐aryl sulfonyl chlorides are successfully coupled with quinoxalin‐2(1H)‐ones without carbon–halogen bond cleavage.