Abstract
The reactions of Li 2PdCl 4 and Na 2PtCl 4 with pyridine-2-carbaldehyde thiosemicarbazone, HPyTsc, afforded the complexes [Pd(PyTsc)Cl], [Pd(PyTsc) 2] and [Pt(PyTsc)Cl], [Pt(PyTsc) 2]. The new complexes have been characterized by elemental analyses and spectroscopic studies. A crystal structure of [Pd(PyTsc)Cl] shows that the anion of PyTsc coordinates in a planar conformation to the central palladium(II) through the pyridyl N, azomethine N and thiolato S atoms. The planar molecules are linked into polymeric chains by N–H ··N and N–H ··S hydrogen bonding. The protonation constants of the ligand, K a1 and K a2, were determined by spectrophotometry and the logarithms of their values were found to be equal to 11.58±0.05 and 3.94±0.02 respectively. Correlation of the antitumor activity of these complexes to the structure and to reduction potential is reported. The compounds [Pt(PyTsc) 2] and [Pd(PyTsc) 2] were found to exhibit the higher in vivo antitumor activity and the lower cytotoxicity.
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