Palladium catalyzed selective formation of homogannular conjugated dienes from allylic esters in decalin derivatives. And its application to the synthesis of 1-α-hydroxy-provitamin D 3.

Abstract

A highly selective synthetic method for homoannular conjugated dienes by the palladium catalyzed elimination of allylic esters is presented. 1-α-Hydroxy-provitamin D 3 was prepared using the palladium catalyzed as a key reaction.