Palladium‐Catalyzed Regioselective C4 Functionalization of Indoles with Quinones

Abstract

A novel synthetic strategy for the installation of diversely functionalized quinones at the C4 position of indoles is developed via palladium-catalyzed C−H and double C−H functionalization. This synthetic protocol provides a rapid route to a variety of 4-quinonylindoles via the direct coupling of 3-formylindoles with quinones. Furthermore, this synthetic methodology also efficiently affords biologically interesting bis(indol-4-yl)quinones in good yields by direct one-pot double C−H activation of 3-formylindoles with the corresponding quinones.