Palladium-catalyzed picolinamide-directed coupling of C(sp(2))-H and C(sp(2))-H: a straightforward approach to quinolinone and pyridone scaffolds.

Abstract

An unprecedented palladium-catalyzed picolinamide-directed coupling of C(sp(2))-H and C(sp(2))-H has been developed with exclusive formation of the six-membered ring heterocyclics - quinolinone and pyridone. The method employs cyclic hypervalent iodine as oxidant and features good functional-group tolerance. Another advantage of this reaction is that sequential C-H/C-H and C-H/N-H coupling could be achieved.