Abstract
A palladium-catalyzed direct and selective ortho-C(sp2)-H silylation of aromatic ketones has been achieved using an aminooxyamide auxiliary. The reaction tolerates various orth-, meta-, and para- substituents on the aromatic ring and can be applied to thiophenyl and vinyl ketones. The ortho-C(sp2)-H bond was monosilylated selectively in comparison with other aromatic C-H bonds, benzyl or allylic C(sp3)-H bonds, and acidic α-C(sp3)-H bonds. The aminooxyamide auxiliary can be easily installed and readily removed after the silylation reaction. The resulting ortho-silyl aromatic ketone derivatives are potentially useful building blocks for organic synthesis.
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