Palladium‐Catalyzed Long‐Range Isomerization of Aryl Olefins

Abstract

Comprehensive SummaryLong‐range olefin isomerization could lead to the remote functionalization of hydrocarbon chains, which is advantageous with regards to atom‐, step‐, and redox economy. However, present methodologies for long‐range olefin isomerization are mainly focused on heteroatom directed remote olefin migration; studies using aryl groups as the directing group are limited. The limited examples either utilize aryl olefins with special substituted groups on a benzene ring, or use elaborately optimized ligands or co‐catalysts to accelerate the isomerization. A more simple catalytic system for general aryl olefins, without the need for special ligands or co‐catalysts, was to be developed. Herein, we report a Pd‐catalyzed long‐range olefin isomerization (up to 15 units) for general aryl olefins via a 1,2‐hydrogen shift mechanism. This methodology provides a simple pathway to long‐range olefin isomerization without the participation of special ligands or co‐catalysts.