Abstract
A Pd(0)-catalyzed cascade reaction of (Z)-1-iodo-1,6-diene bearing a N-heteroaryl ring, including indole, pyrrole as well as imidazole, is reported. The reaction proceeds via Heck-type carbopalladation, which is followed by C-H activation of the attached N-hetero ring, thus delivering 6,5-spirocycles in moderate to good yields. Furthermore, the preliminary attempt at asymmetric version was also conducted.
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