Abstract
AbstractA palladium‐catalyzed intramolecular Mizoroki‐Heck‐type reaction of diarylmethyl tert‐butyl carbonates has been developed. The reaction proceeds under external base‐free, neutral conditions to form the corresponding methyleneindanes in good yields only with liberation of CO2 and tBuOH. The resulting exo‐methylene moiety is reactive and thus a good synthetic handle for further manipulations. Additionally, the asymmetric synthesis is also possible through a Pd/chiral Mandyphos ligand‐mediated kinetic resolution. To the best of our knowledge, this is the first successful example of catalytic enantioselective Mizoroki‐Heck‐type reaction of secondary benzyl electrophiles.magnified image
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