Abstract
A new and efficient reaction has been developed to synthesize α-alkoxy-β-amino acid esters via palladium-catalyzed selective formal insertion of carbenoids into N,O-aminals under mild reaction conditions. A broad range of α-diazoesters with different substituents and various N,O-aminals were compatible with this protocol, affording the corresponding α-alkoxy-β-amino acid esters in good to excellent yields.
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