Palladium‐Catalyzed Dual Catalytic Synthesis of Heterocycles

Abstract

AbstractIn recent years, synergistic dual catalysis has been in the spotlight as a robust strategy for carbon−carbon and carbon−heteroatom bond formation. This review highlights the unique strategies of dual catalysis achieved in the past two decades, involving Pd‐catalyst combined with various first‐ and second‐row transition metals (like Cr, Fe, Cu, Ru, etc.), Lewis acids (based on Yb, Mg, Ti, Al, etc.) or organocatalysts (like squaramide, CPA, and NHC) to achieve valuable heterocyclic cores. Heterocycles find wide applications in pharmaceutical and agrochemical industries. Several organocatalysts like chiral phosphoric acid, NHC, squaramide, etc., and metal salts work in synergy with palladium to provide high‐value products taking advantage of the vast development in cross‐coupling reactions. This review is a comprehensive collection of such dual‐catalysis strategies.