Abstract
A general and efficient protocol based on palladium-catalyzed intramolecular cyclization and reductive aminocarbonylation reaction for the synthesis of acetamide-functionalized benzofurans has been explored. The reaction using iodoarene-tethered propargyl ethers and nitroarenes as the starting materials. This reaction features the formation of structure defined benzofurans with acetamides as attractive functional groups in a single step operation. By using Mo(CO)6 as both CO source and reductant, a variety of acetamides-functionalized benzofurans were obtained in moderate to good yields with good functional group compatibility.
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