Palladium-Catalyzed Cross-Coupling Reaction of AlArEt2(THF) with Aryl Bromides

Abstract

Efficient cross-coupling reactions of aryl bromides with AlArEt2(THF) (Ar = Ph, 4-MeC6H4, 4-MeOC6H4, 4-Me3SiC6H4, or 2-naphthyl) catalyzed by a catalytic system of 1 mol% Pd(OAc)2 and 2 mol% PCy3 furnish aryl-aryl coupling products. The system works well for a wide range of aryl bromides regardless of the electronic or steric nature of the substituent on the aryl bromides.