Abstract
AbstractA palladium‐catalyzed α‐arylation reaction of unactivated sulfones with aryl chlorides is presented. High reactivity and chemoselectivity was achieved with a combination of Buchwald's 2nd generation palladium precatalyst and Kwong's indole‐based phosphine ligand. A variety of aryl chlorides and aryl methyl sulfones were coupled in good to excellent yields. A gram‐scale arylation was also successfully conducted. Chemoselective arylation of the sulfone was observed over Buchwald–Hartwig amination.
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