Palladium-catalyzed carbonylative synthesis of carboxamide substituted 2-pynones from methyl enynoates and nitroarenes

Abstract

A palladium-catalyzed carbonylative synthesis of carboxamide substituted 2-pynones from methyl enynoates and nitroarenes has been developed. With nitroarenes as the nitrogen sources, and Mo(CO)6 as both CO surrogate and reductant, a wide range of carboxamide substituted 2-pynones were obtained in moderate to high yields with quite high functional group compatibility. Moreover, the late-stage modifications of natural molecules was also achieved.