Palladium‐catalyzed CH acetoxylation of arenes using a pyrazolonaphthyridine ligand

Abstract

AbstractHerein, Pd‐catalyzed CH acetoxylation reactions of arenes are developed using a pyrazolonaphthyridine ligand. In the presence of iodomesitylene diacetate as the oxidant, the electron‐deficient ligand facilitates the CH activation of the electron‐rich positions while preventing the formation of Pd black via bidentate binding. Although both acetic acid and hexafluoroisopropanol are employed for directing group‐assisted acetoxylation reactions, the latter proved to be more efficient for the nondirected reaction of arenes with the nitrogen ligand.