Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Reaction of Pyrrole Derivatives.

Abstract

The Pd-catalyzed asymmetric intramolecular dearomatization of pyrroles via the Heck reaction in the presence of commercially available Pd(OAc)2 and the Feringa ligand is described. Diverse pyrroline derivatives were obtained in excellent yields (up to 99%) with high enantioselectivity (up to 96% ee). The reaction features a wide substrate scope, relatively mild conditions, and useful transformations of the products.