Abstract
AbstractA sequence of vinylalumination of α‐substituted aldehydes, ring‐closing metathesis (RCM), and palladium‐catalyzed allylic substitution was utilized to prepare the biologically active natural products, pericosines, from d‐ribose. The anti‐adduct of vinylalumination was transformed into pericosine A after RCM, removal of the 4‐methoxybenzyl protecting group, and chlorination. The diacetate of the anti‐adduct was converted to pericosine C after the palladium‐catalyzed, SN2′‐type, allylic substitution. However, an unexpected dimeric product was generated in utilizing this approach to prepare pericosine E.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
